Field
Health Care, Method, Material
Keywords
Allergic Disease, Atopic Dermatitis, Bronchial Asthma, Alimentary Allergy, Inflammation, Cytokine, Screening Method, Cell Line


Abstracts
Screening for an allergic disease-related substance from candidate substances is carried out based on the reactivity to a plurality of cell lines, which are basophil-like or mast cell-like cell lines derived from the same spleen tissue and have different sensitivities to allergic cytokines. Further, screening for an allergic disease-related substance from candidate substances is carried out using at least one basophil-like or mast cell-like cell line selected from the group consisting of R cell (Deposit No. FERM BP-10918), N 62.5 cell (Deposit No. FERM BP-10919) and RCCM cell (Deposit No. FERM BP-10920).

Advantages
This invention relates to a method for screening allergic disease-related molecule and cell lines to be used in the method.


Inventor
Prof. Ryo Abe (Tokyo University of science)


Patent Publication No
(APPLICATION NUMBER, FILING DATE)
WO200772132 (Nov. 14, 2007), JP2008-544183 (Nov. 14, 2007), EP7831862.3 (Nov. 14, 2007), US12/514799 (Nov. 14, 2007)
(PUBLICATION NUMBER, PUBLICATION DATE)
WO2008059900 (A1) (May 22, 2008), EP2088203 (Aug. 12, 2009）
(PRIORITY APPLICATION NUMBER, PRIORITY DATE)
①JP2006-0308221 (Nov.14, 2006) , ②JP2007-0054244 (Mar. 5, 2007)

Internal file number
G2007-004, T2008-138, (T2006-015, T2006-120)

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