The spheroids culture system is very useful for application to tissue engineering and for simulation model of vital reaction by such as screening of environmental toxic chemicals.

Field
    Health Care
Keywords
    Cells, Spheroid Formation, Branched Polyalkylene Glycol Derivatives, Hydrophilicity, Substrate, Cross Linker


Abstracts
Disclosed is a substrate comprising a base material and a crosslinked material arranged on the base material, wherein the crosslinked material comprises a branched polyalkylene glycol derivative having: three or more polyalkylene glycol groups each having a polymerizable substituent at the terminal; and a linkage group having a valency of 3 or more and capable of binding to the polyalkylene groups. The substrate can be patterned with a high degree of accuracy and can keep the unadhered state of a cell thereon stably for a long term.

Advantages
The present invention relates to a branched polyalkylene glycol derivative, a photosensitive composition, a crosslinked material, and a substrate.
The substrate can be patterned with high degree of accuracy and can keep the anadhered state of cells or spheroids thereon stably for long term.


Inventor
Associate Prof. Hidenori Otsuka et al.
(Tokyo University of Science)


Patent Publication No
(APPLICATION NUMBER, FILING DATE)
WO2008072123 (Dec. 5, 2008)
(PUBLICATION NUMBER, PUBLICATION DATE)
WO2009/072590 (Jun. 11, 2009)
(PRIORITY APPLICATION NUMBER, PRIORITY DATE)
JP2007-316316 (Dec. 6, 2007)

Internal file number
G2008-017 (T2007-073)

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