Technology Summary:
The heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family of growth factors that binds to and activates the EGF receptor (EGFR) and the related receptor tyrosine kinase, ErbB4. Membrane type HB-EGF is the role of receptor for Diphteria toxin (DT). A nontoxic mutant protein of DT binds to HB-EGF and this complex goes into target cells. A nontoxic mutant protein of DT, specific inhibitor of HB-EGF, has been under development for clinical study.

Inventors demonstrate that the expression of HB-EGF is up-regulated on cardiac muscle cells of human and mice failing heart samples. Furthermore, HB-EGF has also been highly expressed on ovarian cancer, uterine cancer and breast cancer cells.

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